发明申请
US20060079528A1 Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
失效
包含双环杂芳基作为hdac抑制剂的氨基甲酸化合物
- 专利标题: Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
- 专利标题(中): 包含双环杂芳基作为hdac抑制剂的氨基甲酸化合物
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申请号: US10546153申请日: 2004-02-25
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公开(公告)号: US20060079528A1公开(公告)日: 2006-04-13
- 发明人: Paul Finn , Ivars Kalvinsh , Einars Loza , Victor Andrianov , Olga Habarova , Daina Lolya , Irina Piskunova
- 申请人: Paul Finn , Ivars Kalvinsh , Einars Loza , Victor Andrianov , Olga Habarova , Daina Lolya , Irina Piskunova
- 国际申请: PCT/GB04/00765 WO 20040225
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; A61K31/502 ; A61K31/498 ; A61K31/4745 ; A61K31/47 ; C07D471/02
摘要:
This invention pertains to certain carbamic acid compounds of the following formula, which inhibit HDAC (histone deacetylase) activity wherein: A is independently an unsubstituted or substituted bicyclic C9-10heteroaryl group (e.g., quinolinyl; quinoxalinyl; benzoxazolyl; benzothiazolyl); Q is an acid leader group, and is independently an unsubstituted or substituted, saturated or unsaturated C17alkylene group having a backbone length of 4 or less; with the proviso that if A is unsubstituted benzothiazol-2-yl, then Q is an unsaturated group; and with the proviso that if A is unsubstituted quinolin-6-yl, then Q is unsubstituted at the a-position; and with the proviso that A is not benzimidazol-2-yl; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.