- 专利标题： Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
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申请号： US11228157申请日： 2005-09-16
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公开(公告)号： US20060084097A1公开(公告)日： 2006-04-20
- 发明人: Rong-Gui Hu , Jun Sheng , Yong Kwon , Anna Kashina , Alexander Varshavsky
- 申请人： Rong-Gui Hu , Jun Sheng , Yong Kwon , Anna Kashina , Alexander Varshavsky
- 申请人地址： US CA Pasadena
- 专利权人： CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人： CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： US CA Pasadena
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/53 ; C40B40/08 ; C40B40/10
摘要：
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent that modulate the activity of the arginylation branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-end rule pathway mediated arginylation.