发明申请
US20060089503A1 Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor
审中-公开
光学活性2-硫代甲基-3-苯基丙酸衍生物的制备方法及其制备方法
- 专利标题： Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor
- 专利标题（中）： 光学活性2-硫代甲基-3-苯基丙酸衍生物的制备方法及其制备方法
-
申请号： US10540023申请日： 2003-12-10
-
公开(公告)号： US20060089503A1公开(公告)日： 2006-04-27
- 发明人: Takahiro Ohishi , Kohei Mori , Koichi Kinoshita , Katsuji Maehara , Hiroaki Kawasaki , Nobuo Nagashima , Yoshihide Fuse
- 申请人： Takahiro Ohishi , Kohei Mori , Koichi Kinoshita , Katsuji Maehara , Hiroaki Kawasaki , Nobuo Nagashima , Yoshihide Fuse
- 申请人地址： JP Osaka 530-8288
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： JP Osaka 530-8288
- 优先权： JP2002-378842 20021227
- 国际申请： PCT/JP03/15821 WO 20031210
- 主分类号： C07D305/12
- IPC分类号： C07D305/12 ; C07D405/02
摘要：
The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active P-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.
信息查询
