发明申请
- 专利标题： PDE4B inhibitors
- 专利标题（中）： PDE4B抑制剂
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申请号： US11219635申请日： 2005-09-02
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公开(公告)号： US20060100218A1公开(公告)日： 2006-05-11
- 发明人: Prabha Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean Artis , Byunghun Lee , Rebecca Zuckerman
- 申请人： Prabha Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean Artis , Byunghun Lee , Rebecca Zuckerman
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K31/4745 ; A61K31/4709 ; A61K31/4439 ; A61K31/423 ; A61K31/405 ; A61K31/416 ; G06F19/00 ; C07D471/02 ; C07D403/02 ; C07D405/02 ; C07D413/02
摘要：
Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
公开/授权文献
- US07605168B2 PDE4B inhibitors 公开/授权日：2009-10-20
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