A programmable gain current amplifier is provided, including a transistor pair, a plurality of differential pairs, and a control device. The transistor pair receives an input current. Each differential pairs connecting with each other in parallel is connected to the transistor pair to form a differential current mirror for amplifying the input current. The control device adjusts the output polarity of the current mirror, thereby obtaining a predetermined gain between the output of the current mirror and the input current. Therefore, amplification of the input current at a programmable gain is realized.