发明申请
US20060110380A1 Compositions for inhibiting thrombin-induced coagulation and methods of use
审中-公开
用于抑制凝血酶诱导的凝血的组合物及其使用方法
- 专利标题: Compositions for inhibiting thrombin-induced coagulation and methods of use
- 专利标题(中): 用于抑制凝血酶诱导的凝血的组合物及其使用方法
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申请号: US11010406申请日: 2004-12-14
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公开(公告)号: US20060110380A1公开(公告)日: 2006-05-25
- 发明人: Stacey Davis , Magnus Hook
- 申请人: Stacey Davis , Magnus Hook
- 主分类号: A61K38/48
- IPC分类号: A61K38/48
摘要:
A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease conditions including stroke, myocardial infarction, sickle-cell crisis and venous thrombosis, is provided by the administration of a fibrinogen-binding protein capable of binding at the N-terminal Bβ chain of fibrinogen, such as SdrG or Fbe, or their respective binding regions such as the A domain. In addition, compositions comprising effective amounts of the fibrinogen-binding proteins are also provided. The present anti-coagulation compositions have been shown to inhibit thrombin-induced fibrin clot formation by interfering with the release of fibrinopeptide B and the resulting anti-coagulation effects can be achieved without potential for causing or exacerbating unwanted side effects such as thrombocytopenia associated with prior art anticoagulants such as heparin.