发明申请
US20060115862A1 Anti-tenascin monoclonal antibody immunoassays and diagnostic kits
审中-公开
抗腱生蛋白单克隆抗体免疫测定和诊断试剂盒
- 专利标题: Anti-tenascin monoclonal antibody immunoassays and diagnostic kits
- 专利标题(中): 抗腱生蛋白单克隆抗体免疫测定和诊断试剂盒
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申请号: US11282117申请日: 2005-11-16
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公开(公告)号: US20060115862A1公开(公告)日: 2006-06-01
- 发明人: Darell Bigner , Charles Pegram , Chien-Tsun Kuan
- 申请人: Darell Bigner , Charles Pegram , Chien-Tsun Kuan
- 申请人地址: US NC Durham
- 专利权人: Duke University
- 当前专利权人: Duke University
- 当前专利权人地址: US NC Durham
- 主分类号: G01N33/574
- IPC分类号: G01N33/574
摘要:
The present invention provides immunoassays for detecting a tumor in a subject, comprising producing an antibody that specifically binds to tenascin, contacting the antibody with a biological sample suspected of containing tumor cells and determining the binding of the antibody to the biological sample. The present invention further provides methods of identifying a subject for treatment of a tumor. Kits for direct or indirect immunohistochemical or immunocytochemical assays are also provided. A novel polyclonal antibody that binds to tenascin domain TNfn C-D is further provided.