发明申请
- 专利标题: Mutant proteinase-inhibitors and uses thereof
- 专利标题(中): 突变蛋白酶抑制剂及其用途
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申请号: US11341567申请日: 2006-01-30
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公开(公告)号: US20060121591A1公开(公告)日: 2006-06-08
- 发明人: Daniel Lawrence , Natalia Gorlatova , David Crandall
- 申请人: Daniel Lawrence , Natalia Gorlatova , David Crandall
- 专利权人: American National Red Cross,WYETH
- 当前专利权人: American National Red Cross,WYETH
- 主分类号: C12N9/99
- IPC分类号: C12N9/99
摘要:
A library of mutants of metastable proteins, such as proteinase inhibitors, can be screened for the specific loss of a wild-type capability to bind an antibody, yielding valuable drug-design information which otherwise is unavailable. By this approach, for example, a mutant proteinase inhibitor can be obtained that has the amino acid sequence of a wild-type protein, or an active fragment thereof, save for the presence of one or more mutations in at least one epitope, thereby altering interaction of the mutant with an anti-proteinase inhibitor antibody.