发明申请
- 专利标题： Kinase modulators
- 专利标题（中）： 激酶调节剂
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申请号： US10533555申请日： 2003-11-14
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公开(公告)号： US20060122171A1公开(公告)日： 2006-06-08
- 发明人: Wei Xu , Lynne Canne Bannen , Samuel Brown , Erick Co , John Nuss , Moon Kim , Rhett Klein , Donna Lee , Amy Tsuhako , Morrison Mac , Jason Parks , Zhaoyang Wen , Wei Cheng
- 申请人： Wei Xu , Lynne Canne Bannen , Samuel Brown , Erick Co , John Nuss , Moon Kim , Rhett Klein , Donna Lee , Amy Tsuhako , Morrison Mac , Jason Parks , Zhaoyang Wen , Wei Cheng
- 国际申请： PCT/US03/36567 WO 20031114
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61K31/454 ; C07D403/14
摘要：
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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