- 专利标题: Phenyl substituted carboxylic acids
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申请号: US11283437申请日: 2005-11-18
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公开(公告)号: US20060122257A1公开(公告)日: 2006-06-08
- 发明人: Michael Van Zandt , Haiquan Fang , Shaojing Hu , Darren Whitehouse
- 申请人: Michael Van Zandt , Haiquan Fang , Shaojing Hu , Darren Whitehouse
- 专利权人: The Institutes for Pharmaceutical Discovery, LLC
- 当前专利权人: The Institutes for Pharmaceutical Discovery, LLC
- 主分类号: A61K31/381
- IPC分类号: A61K31/381 ; A61K31/343 ; A61K31/198 ; C07C235/32 ; C07D333/76
摘要:
Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
公开/授权文献
- US07465825B2 Phenyl substituted carboxylic acids 公开/授权日:2008-12-16
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