The present invention provides for a method for computer program code size partitioning for multiple memory multi-processor systems. At least one system parameter of a computer system comprising one or more disparate processing nodes is identified. Computer program code comprising a program to be run on the computer system is received. A program representation based on received computer program code is generated. At least one single-entry-single-exit (SESE) region is identified based on the whole program representation. At least one SESE region of less than a certain size (store-size-specific) is identified based on identified SESE regions and the at least one system parameter. Each store-size-specific SESE region is grouped into a node-specific subroutine. The non node-specific parts of the computer program code are modified based on the partitioning into node-specific subroutines. The modified computer program code including each node-specific subroutine is compiled based on a specified node characteristic.