发明申请
US20060128635A1 Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
失效
吡唑衍生物,含有该吡唑衍生物的药物组合物,其药学用途及其制造中间体
- 专利标题: Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
- 专利标题(中): 吡唑衍生物,含有该吡唑衍生物的药物组合物,其药学用途及其制造中间体
-
申请号: US10529895申请日: 2003-09-30
-
公开(公告)号: US20060128635A1公开(公告)日: 2006-06-15
- 发明人: Hideki Fujikura , Norihiko Kikuchi , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
- 申请人: Hideki Fujikura , Norihiko Kikuchi , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
- 优先权: JP2002293090 20021004; JP2002330694 20021114; JP2002378959 20021227
- 国际申请: PCT/JP03/12477 WO 20030930
- 主分类号: A61K31/7052
- IPC分类号: A61K31/7052 ; C07H17/02
摘要:
The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selected from the following groups: and the other represents —(CH2)n—Ar wherein Ar represents an optionally substituted C6-10 aryl group or an optionally substituted C1-9 heteroaryl group; and n represents an integral number from 0 to 2, an optionally substituted C1-6 alkoxyl group, an optionally substituted amino group, an optionally substituted C2-9 heterocycloalkyl group or an optionally substituted heterocycle-fused phenyl group; R represents an optionally substituted C3-8 cycloalkyl group, an optionally substituted C6-10 aryl group etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human 1,5-anhydroglucitol/fructose/mannose transporter and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose or a disease associated with hyperglycemia (e.g., diabetic complications, diabetes, etc.), and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
公开/授权文献
信息查询