发明申请
US20060128710A1 Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
审中-公开
对香草素受体亚型1（VR1）的拮抗剂及其用途
- 专利标题： Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
- 专利标题（中）： 对香草素受体亚型1（VR1）的拮抗剂及其用途
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申请号： US11292979申请日： 2005-12-02
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公开(公告)号： US20060128710A1公开(公告)日： 2006-06-15
- 发明人: Chih-Hung Lee , Brian Brown , Ryan Keddy , Richard Perner , John Koenig
- 申请人： Chih-Hung Lee , Brian Brown , Ryan Keddy , Richard Perner , John Koenig
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K31/503 ; A61K31/4745 ; C07D487/02 ; C07D471/02
摘要：
Compounds having formula (I) or formula (II) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A, N, X, Y, R1, R2 and R3 are as defined in the specification. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.