发明申请
US20060128728A1 Pyridinylpyrazolopyrimidinone derivatives as pde 7 inhibitors
审中-公开
吡啶基吡唑并嘧啶酮衍生物作为pde 7抑制剂
- 专利标题： Pyridinylpyrazolopyrimidinone derivatives as pde 7 inhibitors
- 专利标题（中）： 吡啶基吡唑并嘧啶酮衍生物作为pde 7抑制剂
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申请号： US10560386申请日： 2004-06-11
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公开(公告)号： US20060128728A1公开(公告)日： 2006-06-15
- 发明人: Hidekazu Inoue , Hidenobu Murafuji , Yasuhiro Hayashi
- 申请人： Hidekazu Inoue , Hidenobu Murafuji , Yasuhiro Hayashi
- 申请人地址： JP Tokyo 107-8541
- 专利权人： Daiichi Asubio Pharma Co., Ltd
- 当前专利权人： Daiichi Asubio Pharma Co., Ltd
- 当前专利权人地址： JP Tokyo 107-8541
- 优先权： JP2003-170094 20030613
- 国际申请： PCT/JP04/08643 WO 20040611
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/02
摘要：
To provide the compounds inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic disease, inflammatory disease or immunologic disease. The compound is pyridinylpyrazolopyrimidinone compound represented by the following formula (IA) or (IB): especially, R1 is cyclohexyl or cycloheptyl group, R2 is methyl; R3 is a group: —NR5R6 or —S(O)0-2R8; hydrogen atom; nitro group; cyano group; a halogen atom; heteroaryl group; and R4 is methoxy or ethoxy group.
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