- 专利标题： Peptides and related molecules that bind to TALL-1
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申请号： US11272521申请日： 2005-11-10
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公开(公告)号： US20060135431A1公开(公告)日： 2006-06-22
- 发明人: Hosung Min , Hailing Hsu , Fei Xiong
- 申请人： Hosung Min , Hailing Hsu , Fei Xiong
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; C07K7/08
摘要：
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO:100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO:104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO:105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO:106) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ. ID. NO:107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO:109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
公开/授权文献
- US07737111B2 Peptides and related molecules that bind to TALL-1 公开/授权日：2010-06-15
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