发明申请
US20060148858A1 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity
审中-公开
1，具有低血糖和降血脂活性的2-唑衍生物
- 专利标题： 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity
- 专利标题（中）： 1，具有低血糖和降血脂活性的2-唑衍生物
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申请号： US10517214申请日： 2003-05-22
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公开(公告)号： US20060148858A1公开(公告)日： 2006-07-06
- 发明人: Tsuyoshi Maekawa , Ryoma Hara , Hiroyuki Odaka , Hiroyuki Kimura , Hideya Mizufune , Kohji Fukatsu
- 申请人： Tsuyoshi Maekawa , Ryoma Hara , Hiroyuki Odaka , Hiroyuki Kimura , Hideya Mizufune , Kohji Fukatsu
- 优先权： JP2002-151405 20020524; JP2002-287161 20020930; JP2003-16748 20030124
- 国际申请： PCT/JP03/06389 WO 20030522
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/42 ; C07D413/02 ; C07D403/02
摘要：
A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, —O—, —S— and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents —OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.