发明申请
US20060153807A1 Vector-mediated gene regulation in midbrain dopamine neurons
审中-公开
载体介导的中脑多巴胺神经元基因调控
- 专利标题： Vector-mediated gene regulation in midbrain dopamine neurons
- 专利标题（中）： 载体介导的中脑多巴胺神经元基因调控
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申请号： US11034501申请日： 2005-01-12
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公开(公告)号： US20060153807A1公开(公告)日： 2006-07-13
- 发明人: Asa Abeliovich , Jean-Jacques Bacci
- 申请人： Asa Abeliovich , Jean-Jacques Bacci
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
The present invention provides compositions and methods for vector mediated gene regulation in neurons. Specifically, the present invention provides therapeutic compositions comprising viral vectors that allow for the over-expression and RNAi mediated knockdown of genes in vivo. The present invention further provides methods for treating or preventing neurodegeneration in a subject, and for protecting neurons from damage in the context of neurodegenerative disorders. Additionally, the present invention provides a composition, and use of the composition in improving animal models of neurodegeneration.