发明申请
- 专利标题： Liposome formulations of boronic acid compounds
- 专利标题（中）： 硼酸化合物的脂质体制剂
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申请号： US11267794申请日： 2005-11-04
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公开(公告)号： US20060153907A1公开(公告)日： 2006-07-13
- 发明人: Samuel Zalipsky , Francis Martin
- 申请人： Samuel Zalipsky , Francis Martin
- 主分类号： A61K31/69
- IPC分类号： A61K31/69 ; A61K9/127
摘要：
A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a malignancy in a subject.
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