发明申请
US20060153913A1 Solid formulation with improved solubility and stability, and method for producing said formulation
审中-公开
具有改进的溶解度和稳定性的固体制剂以及生产所述制剂的方法
- 专利标题: Solid formulation with improved solubility and stability, and method for producing said formulation
- 专利标题(中): 具有改进的溶解度和稳定性的固体制剂以及生产所述制剂的方法
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申请号: US11256201申请日: 2005-10-24
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公开(公告)号: US20060153913A1公开(公告)日: 2006-07-13
- 发明人: Shogo Yamane , Hirofumi Yamane , Masaki Sunami
- 申请人: Shogo Yamane , Hirofumi Yamane , Masaki Sunami
- 优先权: JPJP2004-310254 20041025
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61K31/454 ; A61K9/20
摘要:
The present invention relates to a solid formulation with improved solubility and maintained stability including a chemical substance poorly soluble in water as a pharmaceutically active ingredient formulated in an improved manner. More specifically, the present invention relates to a solid formulation having improved water-solubility which comprises a chemical substance poorly soluble in water as a pharmaceutically active ingredient, a water-soluble polymer substance and an inorganic porous substance, characterized in that (1) the chemical substance poorly soluble in water forms a solid dispersion together with the water-soluble polymer substance, (2) the water-soluble polymer substance forming the solid dispersion is in the form of fine pieces, and (3) the water-soluble polymer substance is in the form of fine pieces is maintained to be adsorbed on and/or adhered to the surface of the inorganic porous substance. The solid formulation can be produced by stirring and mixing a solution obtained by dissolving a chemical substance poorly soluble in water as a pharmaceutically active ingredient and a water-soluble polymer substance in an organic solvent with an inorganic porous substance and then granulating and drying the mixture.
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