发明申请
- 专利标题： Liposome formulations of boronic acid compounds
- 专利标题（中）： 硼酸化合物的脂质体制剂
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申请号： US11267076申请日： 2005-11-04
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公开(公告)号： US20060159736A1公开(公告)日： 2006-07-20
- 发明人: Samuel Zalipsky , Francis Martin
- 申请人： Samuel Zalipsky , Francis Martin
- 主分类号： A61K31/7024
- IPC分类号： A61K31/7024 ; A61K31/69 ; A61K9/127
摘要：
A liposome composition comprised of liposomes having the peptide boronic acid proteasome inhibitor compound bortezomib entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a solid tumor in a subject.
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