It is intended to provide an ocular hypotensive agent serving as a prophylactic or therapeutic agent for glaucoma, ocular hypertension, etc. which contains a compound of the formula (1): wherein A is methylene group, ethylene group or oxygen atom, n is an integer of 3 or 4, R is phenyl group optionally substituted, 2-pyridyl group optionally substituted or 2-pyrimidinyl group optionally substituted, and a solid line with a dotted line in the bicyclo ring means a single bond or a double bond.