发明申请
- 专利标题: Hydrolytically degradable polymers and hydrogels made therefrom
- 专利标题(中): 水解可降解的聚合物和水凝胶
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申请号: US11377973申请日: 2006-03-17
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公开(公告)号: US20060160983A1公开(公告)日: 2006-07-20
- 发明人: J. Harris , Michael Bentley , Xuan Zhao , Xiaoming Shen
- 申请人: J. Harris , Michael Bentley , Xuan Zhao , Xiaoming Shen
- 主分类号: C08G64/00
- IPC分类号: C08G64/00
摘要:
A water soluble polymer is provided having two or more oligomers linked to each other by hydrolytically degradable carbonate linkages. The polymer can be hydrolytically degraded into oligomers (e.g., oligomers of ethylene oxide) under physiological conditions. The polymer can be conjugated to biologically active agents such as proteins or peptides to impart improved water solubility, reduced immunogenicity, reduced rate of renal clearance, and increased stability. The polymer is useful in making hydrolytically degradable hydrogels which can be used in drug delivery and related biomedical applications. On example of the polymer is a poly (ether carbonate) of the formula X—O—[(—CH2CH2-0-)n—CO2—]n—(CH2CH2))n-y where X and Y are independently H, alkyl, alkenyl, aryl, or a reactive moiety, and at least one of X and Y is a reactive moiety.
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