发明申请
US20060162000A1 Development and use of a new orthotopic, genetically tractable non-human animal model for liver cancer
审中-公开
开发和使用新的原位，遗传易感的非人动物肝癌模型
- 专利标题： Development and use of a new orthotopic, genetically tractable non-human animal model for liver cancer
- 专利标题（中）： 开发和使用新的原位，遗传易感的非人动物肝癌模型
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申请号： US11325218申请日： 2006-01-03
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公开(公告)号： US20060162000A1公开(公告)日： 2006-07-20
- 发明人: Lars Zender , Scott Lowe , Mona Spector
- 申请人： Lars Zender , Scott Lowe , Mona Spector
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C12N15/87
摘要：
This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.