An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.