发明申请
US20060166909A1 Oligonucleotide inhibitors of mbd2/dna demethylase and uses thereof
失效
mbd2 / dna脱甲基酶的寡核苷酸抑制剂及其用途
- 专利标题： Oligonucleotide inhibitors of mbd2/dna demethylase and uses thereof
- 专利标题（中）： mbd2 / dna脱甲基酶的寡核苷酸抑制剂及其用途
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申请号： US10518470申请日： 2003-06-20
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公开(公告)号： US20060166909A1公开(公告)日： 2006-07-27
- 发明人: Moshe Szyf , Paul Campbell
- 申请人： Moshe Szyf , Paul Campbell
- 国际申请： PCT/CA03/00884 WO 20030620
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/68 ; C07H21/02
摘要：
Oligonucleotide inhibitors that inhibit expression of a mammalian MBD2/DNA demethylase (MBD2/dMTase) are provided. The oligonucleotide inhibitors can be used to inhibit the growth or proliferation of tumour cells in vitro and in vivo. The use of the oligonucleotide inhibitors in the treatment of cancer and methods of identifying potential target genes for cancer therapy or diagnosis using the oligonucleotide inhibitors are also provided.
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