- 专利标题: RNAi modulation of RSV and therapeutic uses thereof
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申请号: US11326956申请日: 2006-01-06
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公开(公告)号: US20060166921A1公开(公告)日: 2006-07-27
- 发明人: Rachel Meyers
- 申请人: Rachel Meyers
- 主分类号: A61K48/00
- IPC分类号: A61K48/00
摘要:
The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.
公开/授权文献
- US07507809B2 RNAi modulation of RSV and therapeutic uses thereof 公开/授权日:2009-03-24