发明申请
US20060167282A1 Process for industrially producing optically active 1,4- benzodioxane derivative
审中-公开
工业生产光学活性1,4-苯并二恶烷衍生物的方法
- 专利标题： Process for industrially producing optically active 1,4- benzodioxane derivative
- 专利标题（中）： 工业生产光学活性1,4-苯并二恶烷衍生物的方法
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申请号： US10522734申请日： 2003-07-17
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公开(公告)号： US20060167282A1公开(公告)日： 2006-07-27
- 发明人: Tatsuyoshi Tanaka , Masaru Mitsuda
- 申请人： Tatsuyoshi Tanaka , Masaru Mitsuda
- 国际申请： PCT/JP03/09125 WO 20030717
- 主分类号： C07D319/14
- IPC分类号： C07D319/14
摘要：
A simple and safe method for producing optically active 1,4-benzodioxane derivatives useful as intermediates for pharmaceuticals and the like from inexpensive materials is provided. An optically active triol compound (5) produced by reaction of catechol (2) and optically active 3-halogeno-1,2-propanediol (3) is sulfonylated to form optically active trisulfonate (6), followed by cyclization with a base to yield optically active 1,4-benzodioxane (1).
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