Techniques are presented for assigning reputations to email senders. In one implementation, real-time statistics and heuristics are constructed, stored, analyzed, and used to formulate a sender reputation level for use in evaluating and controlling a given sender's connection to an message transfer agent or email recipient. A sender with an unfavorable reputation may be denied a connection before resources are spent receiving and processing email messages from the sender. A sender with a favorable reputation may be rewarded by having safeguards removed from the connection, which also saves system resources. The statistics and heuristics may include real-time analysis of traffic patterns and delivery characteristics used by an email sender, analysis of content, and historical or time-sliced views of all of the above.