发明申请
- 专利标题： Crystallization and purification of macrolides
- 专利标题（中）： 大环内酯的结晶和纯化
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申请号： US11326723申请日： 2006-01-05
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公开(公告)号： US20060169199A1公开(公告)日： 2006-08-03
- 发明人: Vilmos Keri , Istvan Melczer , Adrienne Kovacsne-Mezei , Andrea Csorvasi
- 申请人： Vilmos Keri , Istvan Melczer , Adrienne Kovacsne-Mezei , Andrea Csorvasi
- 主分类号： C30B15/00
- IPC分类号： C30B15/00 ; C30B21/06 ; C30B27/02 ; C30B28/10 ; C30B30/04
摘要：
The invention provides a method for crystallization and purification of tacrolimus that includes the step of providing a combination of a macrolide and a polar solvent, dopolar aprotic solvent, or hydrocarbon solvent at pH of 7 or above. The invention also provides a novel crystalline form of tacrolimus.
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