A banknote handling apparatus comprises: a deposit-and-withdrawal port unit to or from which banknotes to be transacted are injected or discharged; and a banknote handling unit connected to the deposit-and-withdrawal port unit through a conveying route to discriminate the validity of a banknote and take in and discharge the banknote, wherein the conveying route of the deposit-and-withdrawal port unit is spaced from the conveying route of the banknote handing unit, and the conveying route of the deposit-and-withdrawal port unit and that of the banknote handling unit are connected through a connection conveying route unit, and wherein the banknote handling unit is placed inside of a wall, and only the deposit-and-withdrawal port unit is placed in the through-hole of the wall, thereby the opening area of the through-hole of the wall is decreased.