发明申请
US20060171923A1 Methods of identifying modulators of human retrovirus replication
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鉴定人类逆转录病毒复制调节剂的方法
- 专利标题： Methods of identifying modulators of human retrovirus replication
- 专利标题（中）： 鉴定人类逆转录病毒复制调节剂的方法
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申请号： US10849567申请日： 2004-05-18
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公开(公告)号： US20060171923A1公开(公告)日： 2006-08-03
- 发明人: Sheng Chao , Jeremy Caldwell
- 申请人： Sheng Chao , Jeremy Caldwell
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC, a Delaware Limited Liability Company
- 当前专利权人： IRM LLC, a Delaware Limited Liability Company
- 当前专利权人地址： BM Hamilton
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/70
摘要：
This invention relates to the discovery that the transcription factors Pbx1 and HMG1 are involved in retrovirus, e.g., HIV, replication. Thus, the invention provides methods of identifying modulators of these proteins. Such modulators can be used as reagents in in vitro assays to modulate expression of retroviral sequences and may be used to inhibit HIV replication in vivo.
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