发明申请
- 专利标题: Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
- 专利标题(中): 部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂,具有抗血管生成活性,无抗凝作用
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申请号: US11314736申请日: 2005-12-22
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公开(公告)号: US20060172968A1公开(公告)日: 2006-08-03
- 发明人: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- 申请人: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- 优先权: ITRM2000A000041 20000125; WOPCT/IT01/00034 20010124; WOPCT/IT01/00472 20010912
- 主分类号: A61K31/727
- IPC分类号: A61K31/727 ; A61K31/737
摘要:
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
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