A ventilation, temperature regulation, and ergonomic comfort system for a vehicle seat, comprising a cushion comprising a ventilation layer comprising non-woven plastic fibers fused together in such a manner as to permit airflow therethrough, the ventilation layer having a seat surface side and a reverse side, wherein the ventilation layer is disposed within a substantially air-tight compartment having an access hole for air input on the reverse side of the ventilation layer and a plurality of output holes on the seat surface side; an adjustable ergonomic support device, wherein the ergonomic support device is disposed on the reverse side of the ventilation layer and moves together with the cushion; a temperature regulation system comprising an air-moving device operably coupled to the access hole on the reverse side of the ventilation layer, such that the air-moving device moves conditioned air into the ventilation layer and out through the plurality of output holes; and a control module comprising controls for controlling operation of the temperature regulation system and the ergonomic support device, wherein the seat surface is maintained at a temperature.