发明申请
- 专利标题： Amyloid beta protein (globular assembly and uses thereof)
- 专利标题（中）： 淀粉样蛋白β蛋白（球状组装及其用途）
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申请号： US11100212申请日： 2005-04-06
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公开(公告)号： US20060178302A1公开(公告)日： 2006-08-10
- 发明人: Grant Krafft , William Klein , Brett Chromy , Mary Lambert , Caleb Finch , Todd Morgan , Pat Wals , Irina Rozovsky , Ann Barlow
- 申请人： Grant Krafft , William Klein , Brett Chromy , Mary Lambert , Caleb Finch , Todd Morgan , Pat Wals , Irina Rozovsky , Ann Barlow
- 专利权人： Northwestern University & the University of Southern California
- 当前专利权人： Northwestern University & the University of Southern California
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/47
摘要：
The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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