发明申请
- 专利标题： Apogossypolone and the uses thereof
- 专利标题（中）： 聚鸟苷酮及其用途
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申请号： US11265576申请日： 2005-11-02
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公开(公告)号： US20060178435A1公开(公告)日： 2006-08-10
- 发明人: Shaomeng Wang , Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang
- 申请人： Shaomeng Wang , Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang
- 申请人地址： US MI Ann Arbor 48109-1280
- 专利权人： The Regents of the University of Michigan
- 当前专利权人： The Regents of the University of Michigan
- 当前专利权人地址： US MI Ann Arbor 48109-1280
- 主分类号： C07C50/32
- IPC分类号： C07C50/32 ; A61K31/12 ; A61K31/122 ; A61K31/22
摘要：
The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
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