发明申请
- 专利标题： Cpg-packaged liposomes
- 专利标题（中）： Cpg包装的脂质体
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申请号： US10565264申请日： 2004-07-22
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公开(公告)号： US20060182793A1公开(公告)日： 2006-08-17
- 发明人: Martin Bachmann , Vania Manolova , Tazio Storni
- 申请人： Martin Bachmann , Vania Manolova , Tazio Storni
- 申请人地址： CH Zurich-Schliern CH8952
- 专利权人： Cytos Biotechnology AG
- 当前专利权人： Cytos Biotechnology AG
- 当前专利权人地址： CH Zurich-Schliern CH8952
- 国际申请： PCT/EP04/08190 WO 20040722
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K9/127
摘要：
Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFNα in vivo. These findings are relevant for the humans situation, since IFNα rather than IL-12 is the key cytokine for the induction of Th1 responses and anti-viral protection in humans.
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