发明申请
- 专利标题： Liquid composition of factor VII polypeptides
- 专利标题（中）： 因子VII多肽的液体组成
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申请号： US11304429申请日： 2005-12-15
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公开(公告)号： US20060183683A1公开(公告)日： 2006-08-17
- 发明人: Birthe Hansen , Michael Jensen , Troels Kornfelt
- 申请人： Birthe Hansen , Michael Jensen , Troels Kornfelt
- 申请人地址： CH Zurich
- 专利权人： Novo Nordisk HealthCare A/G
- 当前专利权人： Novo Nordisk HealthCare A/G
- 当前专利权人地址： CH Zurich
- 优先权： DKPA200300959 20030625; WOPCT/DK04/00181 20040318
- 主分类号： A61K38/36
- IPC分类号： A61K38/36 ; A61K31/19
摘要：
The invention concerns a liquid aqueous composition comprising (i) a factor VII polypeptide, (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 9.0; (iii) an agent selected from the group consisting of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is less than 15 mM; and (iv) An ionic strength modifying agent; wherein the ionic strength of the composition is at least 200 mM.