发明申请
- 专利标题: Methods of treating epileptogenesis and epilepsy
- 专利标题(中): 治疗癫痫发作和癫痫的方法
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申请号: US11227247申请日: 2005-09-15
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公开(公告)号: US20060194873A1公开(公告)日: 2006-08-31
- 发明人: Yong Choi , Robert Gordon , Gerald Novak , Carlos Plata-Salaman , Roy Twyman , H. White , Boyu Zhao
- 申请人: Yong Choi , Robert Gordon , Gerald Novak , Carlos Plata-Salaman , Roy Twyman , H. White , Boyu Zhao
- 主分类号: A61K31/325
- IPC分类号: A61K31/325
摘要:
This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
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