发明申请
- 专利标题： Coated implantable medical device
- 专利标题（中）： 涂层可植入医疗器械
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申请号： US11410354申请日： 2006-04-25
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公开(公告)号： US20060195176A1公开(公告)日： 2006-08-31
- 发明人: Brian Bates , Anthony Ragheb , Neal Fearnot , Thomas Kozma , William Voorhees
- 申请人： Brian Bates , Anthony Ragheb , Neal Fearnot , Thomas Kozma , William Voorhees
- 申请人地址： US IN Bloomington 47404 US IN West Lafayette 47906
- 专利权人： Cook Incorporated,MED Institute, Inc.
- 当前专利权人： Cook Incorporated,MED Institute, Inc.
- 当前专利权人地址： US IN Bloomington 47404 US IN West Lafayette 47906
- 主分类号： A61F2/82
- IPC分类号： A61F2/82
摘要：
Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 μg/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 μm to about 5 μm.