发明申请
- 专利标题： Target validation assay
- 专利标题（中）： 目标验证测定
-
申请号： US11326795申请日： 2006-01-06
-
公开(公告)号： US20060198789A1公开(公告)日： 2006-09-07
- 发明人: Zhigang Weng , Jeno Gyuris , Steven Clark
- 申请人： Zhigang Weng , Jeno Gyuris , Steven Clark
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C12Q1/68 ; C12N5/08 ; C12N15/87
摘要：
An method of determining whether a gene of interest is necessary for a tumor cell to maintain its tumorigenicity is disclosed. The method is useful for validation of cancer therapeutic targets in vivo, using shRNAs and tumor xenografts. The inducible shRNA method operates an in vivo RNAi competition assay.
信息查询
