发明申请
US20060199812A1 Method of conjugating aminothiol containing molecules to vehicles
审中-公开
将含氨基硫醇的分子与载体共轭的方法
- 专利标题： Method of conjugating aminothiol containing molecules to vehicles
- 专利标题（中）： 将含氨基硫醇的分子与载体共轭的方法
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申请号： US11338371申请日： 2006-01-23
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公开(公告)号： US20060199812A1公开(公告)日： 2006-09-07
- 发明人: Derin D'Amico , Benny Askew
- 申请人： Derin D'Amico , Benny Askew
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 主分类号： A61K31/542
- IPC分类号： A61K31/542 ; C07D498/14 ; C07D498/04
摘要：
The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or 1,3 aminothiol group. The invention further relates to the methods of using novel water-soluble polymer derivatives and conjugates thereof.
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