Various embodiments of a medical device having a deflecting shaft and related methods of manufacture and use are disclosed. For example, the device may include a proximal handle, a distal assembly for performing a medical procedure and a wire-coil connecting the proximal handle to the distal assembly, wherein actuation of the proximal handle may cause the distal assembly to perform the medical procedure. The wire coil may have a proximal portion comprised of a first wire and a distal portion comprised of a second wire. The second wire may have a diameter less than a diameter of the first wire so that the distal portion of the wire coil may have a flexibility greater than a flexibility of the proximal portion.