- 专利标题: System and method to simulate hemodynamics
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申请号: US11440148申请日: 2006-05-25
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公开(公告)号: US20060210959A1公开(公告)日: 2006-09-21
- 发明人: Michael Dancu , John Tarbell
- 申请人: Michael Dancu , John Tarbell
- 专利权人: Victor KRSTEC
- 当前专利权人: Victor KRSTEC
- 主分类号: A01N1/02
- IPC分类号: A01N1/02 ; C12M3/00 ; C12M1/36
摘要:
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.