发明申请
US20060211717A1 Quinoline and quinazoline derivatives and drugs containing the same
审中-公开
喹啉和喹唑啉衍生物和含有相同的药物
- 专利标题: Quinoline and quinazoline derivatives and drugs containing the same
- 专利标题(中): 喹啉和喹唑啉衍生物和含有相同的药物
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申请号: US11432407申请日: 2006-05-12
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公开(公告)号: US20060211717A1公开(公告)日: 2006-09-21
- 发明人: Teruyuki Sakai , Terufumi Senga , Takayuki Furuta , Atsushi Miwa
- 申请人: Teruyuki Sakai , Terufumi Senga , Takayuki Furuta , Atsushi Miwa
- 申请人地址: JP Tokyo
- 专利权人: KIRIN BEER KABUSHIKI KAISHA
- 当前专利权人: KIRIN BEER KABUSHIKI KAISHA
- 当前专利权人地址: JP Tokyo
- 优先权: JP11/377486 19991224; JP2000/177790 20000614; JP11374494 19991228
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; C07D403/02
摘要:
There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R1 and R2 represent hydrogen, alkyl or the like; R3, R4, R5, and R6 represent hydrogen, halogen, alkyl, alkoxy or the like; R11 and R12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5 and R6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.