发明申请
US20060211734A1 (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht1f agonists
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（哌啶基氧基）苯基，（哌啶基氧基）吡啶基，（哌啶基硫烷基）苯基和（哌啶基硫烷基）吡啶基化合物作为5-ht1f激动剂
- 专利标题： (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht1f agonists
- 专利标题（中）： （哌啶基氧基）苯基，（哌啶基氧基）吡啶基，（哌啶基硫烷基）苯基和（哌啶基硫烷基）吡啶基化合物作为5-ht1f激动剂
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申请号： US10552131申请日： 2004-04-14
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公开(公告)号： US20060211734A1公开(公告)日： 2006-09-21
- 发明人: Maria-Jesus Blanco-Pillado , Dana Benesh , Sandra Filla , Kevin Hudziak , Brian Mathes , Daniel Kohlman , Bai-Ping Ying , Deyl Zhang , Yao-Chang Xu
- 申请人： Maria-Jesus Blanco-Pillado , Dana Benesh , Sandra Filla , Kevin Hudziak , Brian Mathes , Daniel Kohlman , Bai-Ping Ying , Deyl Zhang , Yao-Chang Xu
- 申请人地址： US IN Indianapolis
- 专利权人： ELILILLY AND COMPANY
- 当前专利权人： ELILILLY AND COMPANY
- 当前专利权人地址： US IN Indianapolis
- 国际申请： PCT/US04/09283 WO 20040414
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; A61K31/454 ; C07D401/14 ; C07D403/14
摘要：
The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.
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