发明申请
US20060213398A1 Calcium phosphate bone cements 失效
磷酸钙骨水泥

  • 专利标题: Calcium phosphate bone cements
  • 专利标题(中): 磷酸钙骨水泥
  • 申请号: US10557833
    申请日: 2004-05-19
  • 公开(公告)号: US20060213398A1
    公开(公告)日: 2006-09-28
  • 发明人: Jake BarraletUwe GbureckRoger Thull
  • 申请人: Jake BarraletUwe GbureckRoger Thull
  • 优先权: GB0311846.0 20030523
  • 国际申请: PCT/GB04/02179 WO 20040519
  • 主分类号: C04B28/34
  • IPC分类号: C04B28/34
Calcium phosphate bone cements
摘要:
In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:—(i) a powdered component, said powdered component having an average particle size d50 of less than 15 μm, and (ii) a calcium phosphate based powder, said powder having an average particle size d50 greater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:—(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least −30 mV.
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