In a door opening and closing device for a vehicle in which a cylinder body of a cylinder lock having a rotor turned in response to a key operation and a casing of a door-locking device which has a door-locking lever shaft turned in response to the turning of the rotor and is switched over between a locking state and an unlocking state in response to the turning of the door-locking lever shaft are mounted to a door, a turning movement-transmitting member having a flexibility is disposed between the cylinder lock and the door-locking device so as to transmit a turning force of the rotor to the door-locking lever shaft by its twisting motion responsive to the turning of the rotor. Thus, it is possible to increase the degree of freedom for the relative dispositions of the cylinder lock and the door-locking device, while eliminating the need for a protector for preventing the unauthorized access from the outside.