The disclosure is directed to techniques for region-of-interest (ROI) processing for video telephone (VT) applications. According to the disclosed techniques, a recipient device defines ROI information for video information transmitted by a sender device, i.e., far-end video information. The recipient device transmits the ROI information to the sender device. Using the ROI information transmitted by the recipient device, the sender device applies preferential encoding to an ROI within a video scene. In this manner, the recipient device is able to remotely control ROI encoding of far-end video information by the sender device.