发明申请
- 专利标题： Exo-selective synthesis of himbacine analogs
- 专利标题（中）： 非选择性合成替卡宾类似物
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申请号： US11330521申请日： 2006-01-12
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公开(公告)号： US20060217422A1公开(公告)日： 2006-09-28
- 发明人: Tiruvettipuram Thiruvengadam , Anantha Sudhakar , Ngiap Lim , Daw-long Kwok , George Wu , Tao Wang , Mingsheng Huang , Michael Green
- 申请人： Tiruvettipuram Thiruvengadam , Anantha Sudhakar , Ngiap Lim , Daw-long Kwok , George Wu , Tao Wang , Mingsheng Huang , Michael Green
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 主分类号： C07D405/02
- IPC分类号： C07D405/02 ; A61K31/4433
摘要：
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
公开/授权文献
- US07772276B2 Exo-selective synthesis of himbacine analogs 公开/授权日：2010-08-10