发明申请
- 专利标题: Indanyl-piperazine compounds
- 专利标题(中): 茚基 - 哌嗪化合物
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申请号: US11391916申请日: 2006-03-29
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公开(公告)号: US20060223830A1公开(公告)日: 2006-10-05
- 发明人: Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
- 申请人: Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
- 优先权: FR05.03071 20050330
- 主分类号: A61K31/495
- IPC分类号: A61K31/495 ; C07D241/04
摘要:
A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
公开/授权文献
- US07442692B2 Indanyl-piperazine compounds 公开/授权日:2008-10-28